Chromosomal analysis after lymphocyte culture is performed in order to detect aneuploidy and/or structural abnormalities and the presence of more than one cell lines (mosaicism) of autosomal and/or sex chromosomes. It is recommended in: 1. Abnormalities during early growth and development (e.g. insufficient growth, developmental delay, dysmorphic facial features, low stature, mental retardation), 2. Early neonatal or fetal  death (chromosomal abnormalities identified in fetal death ≈10%), 3. Infertility problems (e.g. recurrent miscarriages, amenorrhea), 4. Family history (known or suspected chromosomal abnormality in first degree relative), 5. Tumors and 6. Advanced maternal age.